A Mechanistic Model for Cooperative Behavior of Co-transcribing RNA Polymerases
نویسندگان
چکیده
منابع مشابه
A Mechanistic Model for Cooperative Behavior of Co-transcribing RNA Polymerases
In fast-transcribing prokaryotic genes, such as an rrn gene in Escherichia coli, many RNA polymerases (RNAPs) transcribe the DNA simultaneously. Active elongation of RNAPs is often interrupted by pauses, which has been observed to cause RNAP traffic jams; yet some studies indicate that elongation seems to be faster in the presence of multiple RNAPs than elongation by a single RNAP. We propose t...
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RNA polymerase I (Pol I) is a 14-subunit enzyme that solely synthesizes pre-ribosomal RNA. Recently, the crystal structure of apo Pol I gave unprecedented insight into its molecular architecture. Here, we present three cryo-EM structures of elongating Pol I, two at 4.0 Å and one at 4.6 Å resolution, and a Pol I open complex at 3.8 Å resolution. Two modules in Pol I mediate the narrowing of the ...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2016
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1005069